meenaxi
AIPPG Experienced Senior Member
Joined: 21 Feb 2009
Posts: 723
23308 Credits
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 Posted: Tue Nov 03, 2009 1:32 pm Post subject: A 75-year-old man has a painless mass in the left upper ante |
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A 75-year-old man has a painless mass in the left upper anterior neck. Examination of tissue obtained on biopsy shows partial replacement of a lymph node by a neoplasm; the neoplasm is composed of cohesive sheets of polygonal cells with granular eosinophilic cytoplasm, prominent intercellular bridges, and pleomorphic round nuclei. Immunocytochemical preparations show a strongly positive reaction of the neoplastic cells to a high-molecular-weight keratin antibody. There is no reaction to antibodies against vimentin and leukocyte common antigen (CD45). Which of the following is the most likely diagnosis?
A ) Adenocarcinoma
B ) Malignant melanoma
C ) Non-Hodgkin lymphoma
D ) Sarcoma
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