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A randomized, double-blind, controlled trial is conducted to

 
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meenaxi
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PostPosted: Tue Nov 03, 2009 1:27 pm    Post subject: A randomized, double-blind, controlled trial is conducted to

A randomized, double-blind, controlled trial is conducted to assess the efficacy of a drug to prevent osteoporotic fractures in women older than 65 years. Sixty women are enrolled; 30 subjects receive the new drug (group X), and 30 subjects receive a placebo (group Y). Two years later, seven subjects from group X have had fractures, and 15 subjects from group Y have had fractures (p=0.06). The investigators conclude that there is not a significant difference between the treatments, and the new agent is not recommended. Which of the following raises the most concern about the validity of this conclusion?

A ) Inappropriate study population

B ) Low external validity

C ) Low power

D ) Use of blinding

E ) Use of a placebo


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meenaxi
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PostPosted: Tue Nov 03, 2009 1:28 pm    Post subject:

low power for sure. A would be correct if it says Inappropriate study population of too small a size


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