Which of the following is the most likely consequence of imp

[meenaxi]

Which of the following is the most likely consequence of impaired synthesis of IL-1?

A. enhanced phagocytic activity of circulating macrophages
B. enhanced production of antibody by B cells
C. impaired antigen processing by circulating macrophages
D. impaired function of T lymphocyte
E. impaired production of leukotrienes by neutrophils

[meenaxi]

IL - 1 is secreted by macrophages and monocytes.
It
*is endogenous pyrogen
*cytokines increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes
*IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells.