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The genetic disease institute at a university hospital has d

 
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madhurima
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PostPosted: Mon Nov 02, 2009 2:14 pm    Post subject: The genetic disease institute at a university hospital has d

The genetic disease institute at a university hospital has developed a rapid screening test for a serious but treatable inherited metabolic disorder. Although this disorder is predominantly found in a particular ethnic group, it is also found sporadically throughout the entire population. The screening test has a sensitivity of 95% and a specificity of 90%. When used in an ethnically prescreened population where the prevalence of this disorder is 30%, the positive predictive value is 80% and the negative predictive value is 96%. The institute proposes to use this screening test on the general population where the prevalence of this disease is 0.1%. Which of the following is the most likely result of this screening program?

A ) Negative predictive value decreases

B ) Positive predictive value decreases

C ) Sensitivity decreases

D ) Specificity decreases


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madhurima
AIPPG Experienced Senior Member


Joined: 06 Nov 2008
Posts: 1711

54948 Credits

PostPosted: Mon Nov 02, 2009 2:15 pm    Post subject:

A ) Negative predictive value increase

B ) Positive predictive value decreases

C ) Sensitivity doesn't change

D ) Specificity doesn't change

b is right


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