Hijeck
AIPPG Experienced Senior Member
Joined: 02 Oct 2008
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 Posted: Mon Nov 02, 2009 1:40 pm Post subject: In a population, the frequency of the HLA-A locus allele (A* |
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In a population, the frequency of the HLA-A locus allele (A*01) is 0.20 and the frequency of the HLA-B locus allele (B*0 is 0.20. In the same population, the frequency of the haplotype A*01, B*08 is 0.16. Which of the following terms best explains the population characteristics of the observed frequency of the A*01, B*08 haplotype?
a) Linage disequilibrium
b) Random assortment
c) Somatic mutation
d) Variable expressivity
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Hijeck
AIPPG Experienced Senior Member
Joined: 02 Oct 2008
Posts: 521
19197 Credits
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| Posted: Mon Nov 02, 2009 1:42 pm Post subject: |
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Linkage disequilibrium is the non-random association of alleles at two or more loci, not necessarily on the same chromosome.
Random assortment is opposite of Linkage disequilibrium.Ex: In meiosis, the random assortment of the alleles at two or more loci because they are on different chromosome pairs or far apart on the same chromosome pair.
Somatic mutations can occur in any of the cells of the body except the germ cells.
Variable expressivity occurs when a phenotype is expressed to a different degree among individuals with the same genotype.
So B. Random assortment
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