Clomiphene therapy

[same]

Clomiphene therapy:









a. is usually started in a dosage of 100 mg. daily
b. is usually started on day seven of the cycle
c. is usually taken for seven days of the cycle
d. is associated with an increased risk of multiple pregnancy
e. is associated with a risk of ovarian hyperstimulation
f. is a theoretical risk factor for ovarian cancer

[roni]

a. is usually started in a dosage of 100 mg. daily
b. is usually started on day seven of the cycle
c. is usually taken for seven days of the cycle
d. is associated with an increased risk of multiple pregnancy
e. is associated with a risk of ovarian hyperstimulation
f. is a theoretical risk factor for ovarian cancer


a false the dosage is 50 mg/day
b false (it's started on day 5 and used for 5 days)
c false
d true
e true
f (recently there has been a suggestion that clomifene may be associated with an increased risk of ovarian cancer, although this association is far from proven, it has een advised that clomifene should not normally be used for more than six treatment cycles.

[roni]

i forget
f is true

[same]

agreed
It is usually started between days two to five in a dosage of 50 mg. daily and taken for five days each cycle. The dosage can be increased, 50 mg. at a time, up to a maximum dosage of 200 mg. daily. It hoodwinks the pituitary into increasing FSH production, thus encouraging ovulation. It increases the risk of multiple pregnancy (from about 1% to more than 5%) and is associated with ovarian cyst formation and its rare, but extreme, variant, hyperstimulation. There is no evidence that it is teratogenic.

Absence of ovulation due to pregnancy, lactation, breast feeding, the Pill etc. is protective with regard to ovarian cancer. By inducing ovulation, Clomiphene becomes a theoretical risk factor.