Liver biopsy of 45-year-old Caucasian female with fatigue th

Liver biopsy of 45-year-old Caucasian female with fatigue that developed over the course of a year and pale stool reveals dilated bile canaliculi with green-brown plugs and brawny pigmented hepatic parenchyma Which of the following is the most likely associated condition in this patient?

A Cardiac dilation
B Seborrhea
C Osteomalacia
D Amnesia and confabulations
E Gastric atrophy
F Hypochromic anemia

ans is C

Cholestasis can arise secondary hepatocellular dysfunction or biliary obstruction, whether intrahepatic or extrahepatic Both obstructive and nonobstructive cholestasis are characterized by the deposition of bile pigment within the hepatic parenchyma and the presence of green-brown plugs in the dilated bile canaliculi When prolonged, this reduction in bile flow causes intestinal malabsorption and nutritional deficiencies of the fat-soluble vitamins (A, D, E and K) in particular Therefore, those conditions associated with fat-soluble vitamin deficiency - such as osteomalacia - would be mostlikety in a patient with prolonged cholestasis
Osteomalacia is one of the most common causes of reduced bone density and, in adults, is characterized by disordered mineralization of the new~ formed bone matrix