A 59-year-old man went to his physician for a routine health maintenance examination. The only abnormal physical examination finding is a positive stool guaiac test. Laboratory studies show a CBC with Hgb 10.0 g/dL, Hct 29.8&, MCV 73 fL, platelet count 300,000/microliter, and WBC count 8700/microliter. He is found on colonoscopy to have a 4 cm mass lesion arising on the mucosal surface of the transverse colon. Which of the following statements is most appropriate regarding these findings?
A This is an uncommon site for a primary malignant neoplasm
B Microscopically, the mass is probably an adenocarcinoma
C Persons who are smokers are at much greater risk to develop this lesion
D Hypercalcemia is a frequent paraneoplastic complication
E The predicted 5 year survival rate is less than 5%