William’s syndrome has an association with ?

William’s syndrome has an association with ?

a. coarctation of aorta
b. congenital subvalvular aortic stenosis
c. congenital supravalvular aortic stenosis
d. VSD

Ans: c. congenital supravalvular aortic stenosis

Williams syndrome (WS or WMS; also Williams–Beuren syndrome or WBS) is a rare neurodevelopmental disorder caused by a deletion of about 26 genes from the long arm of chromosome 7. It is characterized by a distinctive, "elfin" facial appearance, along with a low nasal bridge; an unusually cheerful demeanor and ease with strangers; developmental delay coupled with unusual (for persons who are diagnosed as developmentally delayed) language skills; and cardiovascular problems, such as supravalvular aortic stenosis and transient hypercalcaemia.